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High quality API Nintedanib powder CAS No 656247-17-5:
Name : Nintedanib, CAS 656247-17-5
Chemical name :
methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate Nintedanib
Other name : Nintedanib 656247-17-5
Key words : API; antineoplastic; treat idiopathic pulmonary fibrosis.
CAS NO. : 656247-17-5
Molecular Formula : C31H33N5O4
Molecular Weight : 539.636 g/mol
Nintedanib is an oral administrated triple tyrosine kinase inhibitors developed by Boehringer Ingelheim, Germany. Its targets include platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and basic fiber (BFGF), being able to also inhibit the activation of MAPK and Akt. At present, it is mainly used for cancer treatment, such as colorectal cancer, ovarian cancer and multiple myeloma. The study regarding to the respiratory diseases mainly focuses on the clinical treatment of advanced non-small cell lung cancer (NSCLC) and idiopathic pulmonary fibrosis (IPF). In June 2014, Boehringer Ingelheim has announced that the marketing authorization application of Nintedanib for the treatment of Idiopathic Pulmonary Fibrosis (IPF) had been confirmed by the European Medicines Agency (EMA) and been included in the accelerated approval list by the EMA.
Treatment of systemic sclerosis.
Treatment of idiopathic pulmonary fibrosis.
Argatef is indicated in combination with docetaxel for the treatment of adult patients with locally advanced, metastatic or locally recurrent non small cell lung cancer (NSCLC) of adenocarcinoma tumour histology after first line chemotherapy.
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Shijiazhuang Dingmin Pharmaceutical Sciences Co., Limited is a professional company ocusing on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. We have a R&D center and two plants in Shijiazhuang, Hebei Province. Our Products include active pharmaceutical ingredients (API), pharmaceutical and agrochemical intermediates and chiral compounds. We have won the trust of a wide range of customers/partners in the industry. Our major products are antineoplastic, cardiovascular and antibiotics and their intermediates.
In order to maintain continuous innovation and R & D capability, we maintain long-term and close cooperation with many research institutions and universities, Our co-production plants are located in Anhui, Jiangsu, Zhejiang and Inner Mongolia. The products have been sold to Europe, America, Southeast Asia and other countries and regions
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