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Home > Products > APIs And Intermediates > Eltrombopag Olamine Intermediates > eltrombopag olamine CAS: 496775-62-3

eltrombopag olamine CAS: 496775-62-3

eltrombopag olamine CAS: 496775-62-3

Payment Type: L/C,T/T,D/P,Paypal
Min. Order: 0.01 Kilogram
Delivery Time: 3 Days

Basic Info

    Model No.: DM 496775-62-3

    Appearance: Red To Brown Crystalline Powder

    Purity: ≥99.0%

    Water: ≤0.5%

    Residue On Ignition: ≤0.1%

    Single Impurity: ≤0.5%

Additional Info

    Packaging: Double PE Bag with Foil Bag or as required

    Productivity: Stock available

    Transportation: Ocean,Air,Courier

    Place of Origin: Hebei,China

    Supply Ability: As per order

    Certificate: ISO9001

    Port: Shanghai,Hangzhou,Shenzhen

Product Description


Eltrombopag is a is an agonist of the c-mpl (TpoR) receptor used as treatment for thrombocytopenia.It has been developed for certain conditions that lead to thrombocytopenia (abnormally low platelet counts).

Product Name: Eltrombopag Olamine
Cas No.: 496775-62-3
Appearance: Red to Brown Crystalline Powder



Residue on ignition:≤0.1%

Heavy Metal:≤10ppm

Single impurity≤0.5%

Total impurities≤1.0%


Package:Double PE Bag with Foil Bag or As required

Delivery time:Stock available

Port:Any port in China

Our productions of Eltrombopag Intermediates:

Eltrombopag Project Eltrombopag Olamine 496775-62-3
Eltrombopag 496775-61-2
3'-amino-2'-hydroxybiphenyl-3-carboxylic acid 376592-93-7
2'-hydroxy-3'-nitro-Biphenyl-3-carboxylic acid 376591-95-6
1-(3,4-dimethylphenyl)-3-methyl-3-pyrazolin-5-tone 18048-64-1
3,4-Dimethylphenylhydrazine hydrochloride 86746-50-1

Description: IC50 Value: 0.27 uM (EC50 in murine BAF3 cells) Eltrombopag is a new, orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis. Potential advantages of eltrombopag may include a sustained platelet response and a good tolerability profile. in vitro: Eltrombopag demonstrated a half maximal effective concentration (EC50) of 0.27 uM in murine BAF3 cells transfected with the luciferase reporter gene under direction of the STAT-activated IRF-1 promoter and human TpoR (BAF3/IRF-1/hTpoR). Eltrombopag stimulates the growth of TPO-dependent cell lines via JAK2 and STAT signaling pathways and stimulates isolated human CD34+ cells to become megakaryocytes and produce platelets. in vivo: Twelve weeks of antiviral therapy, with concurrent receipt of eltrombopag or placebo, were completed by 36%, 53%, and 65% of patients receiving 30 mg, 50 mg, and 75 mg of eltrombopag, respectively, and by 6% of patients in the placebo group. Eltrombopag was administered as once-daily oral capsules for 10 days at doses of 5, 10, 25, 30, 50, and 75 mg. The pharmacokinetics of eltrombopag was dose dependent and linear, and eltrombopag increased platelet counts in a dose-dependent manner. Toxicity: There were no apparent differences in the incidence or severity of adverse events in subjects receiving active or placebo study medication. Long-term treatment with eltrombopag was generally safe, well tolerated, and effective in maintaining platelet counts in the desired range. Clinical trial: Eltrombopag In Cord Blood Or Haploidentical Bone Marrow Transplantation. Phase 2

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