Shijiazhuang Dingmin pharmaceutical Sciences Co.,Ltd

Shijiazhuang Dingmin pharmaceutical Sciences Co.,Ltd

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Shijiazhuang Dingmin pharmaceutical Sciences Co.,Ltd
HomeProductsAPIs And IntermediatesCaftor Series IntermediatesIvacaftor (VX-770) CAS: 873054-44-5

Ivacaftor (VX-770) CAS: 873054-44-5

Payment Type:
L/C,T/T,D/P
Incoterm:
FOB,CIF,CIP
Min. Order:
1 Kilogram
Transportation:
Ocean,Air,Courier
Port:
Shanghai,Shenzhen,Hangzhou
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  • Product Description
Overview
Product Attributes

Model No.DM 873054-44-5

Supply Ability & Additional Information

PackagingAs required

ProductivityStock Available

TransportationOcean,Air,Courier

Place of OriginHebei,China

Supply AbilityAs per order

CertificateISO9001

PortShanghai,Shenzhen,Hangzhou

Payment TypeL/C,T/T,D/P

IncotermFOB,CIF,CIP

Packaging & Delivery
Selling Units:
Kilogram
Package Type:
As required

Strong Products Ivacaftor(VX-770) CAS:873054-44-5 99%+


Product Name: N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Cas No.: 873054-44-5

Appearance:White Powder

Purity:99%+


Package&Shipping:

Package:Double PE Bag with Foil Bag or As required

Delivery time:Stock available 

Port:Any port in China


iva 


Ivacaftor is an orally bioavailable potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) that improves chloride transport.It increases the forskolin-induced CFTR-mediated epithelial current in cells expressing the G551D missense mutation associated with severe cystic fibrosis by approximately 4-fold (EC50 = 100 nM) but has no effect on current in the absence of forskolin. Ivacaftor increases chloride secretion in cultured human cystic fibrosis bronchial epithelial cells carrying the G551D mutation on one allele and the common ΔF508 processing mutation on the other allele. It binds CFTR directly and leads to CFTR channel opening via an ATP-independent mechanism.Formulations containing ivacaftor have been used in the treatment of cystic fibrosis in patients carrying one or more mutations in the CFTR gene.


Our productions of Ivacaftor(VX-770) Intermediates:

Ivacaftor

(VX-770)


N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

CAS: 873054-44-5

Iva-INT


4-oxo-1,4-dihydroquinoline-3-carboxylic acid

CAS: 13721-01 -2

Iva-INT


5-amino-2,4-di-tert-butylphenol hydrochloride

CAS: 873055-58-4 (base)


Other project related

Lumacaftor (VX-809)


3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)

Benzoic Acid

CAS:936727-05-8

Tezacaftor (VX-661)


1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-

dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide

1152311-62-0



Product Categories : APIs And Intermediates > Caftor Series Intermediates

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