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Shijiazhuang Dingmin pharmaceutical Sciences Co.,Ltd
sales@dingminpharma.com
86-311-67591193
Model No.: DM 873054-44-5
Packaging: As required
Productivity: Stock Available
Transportation: Ocean,Air,Courier
Place of Origin: Hebei,China
Supply Ability: As per order
Certificate: ISO9001
Port: Shanghai,Shenzhen,Hangzhou
Payment Type: L/C,T/T,D/P
Incoterm: FOB,CIF,CIP
Strong Products Ivacaftor(VX-770) CAS:873054-44-5 99%+
Product Name: N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
Cas No.: 873054-44-5
Appearance:White Powder
Purity:99%+
Package&Shipping:
Package:Double PE Bag with Foil Bag or As required
Delivery time:Stock available
Port:Any port in China
Ivacaftor is an orally bioavailable potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) that improves chloride transport.It increases the forskolin-induced CFTR-mediated epithelial current in cells expressing the G551D missense mutation associated with severe cystic fibrosis by approximately 4-fold (EC50 = 100 nM) but has no effect on current in the absence of forskolin. Ivacaftor increases chloride secretion in cultured human cystic fibrosis bronchial epithelial cells carrying the G551D mutation on one allele and the common ΔF508 processing mutation on the other allele. It binds CFTR directly and leads to CFTR channel opening via an ATP-independent mechanism.Formulations containing ivacaftor have been used in the treatment of cystic fibrosis in patients carrying one or more mutations in the CFTR gene.
Our productions of Ivacaftor(VX-770) Intermediates:
Ivacaftor (VX-770) | | N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide | CAS: 873054-44-5 |
Iva-INT | | 4-oxo-1,4-dihydroquinoline-3-carboxylic acid | CAS: 13721-01 -2 |
Iva-INT | | 5-amino-2,4-di-tert-butylphenol hydrochloride | CAS: 873055-58-4 (base) |
Other project related
Lumacaftor (VX-809) | | 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl) | CAS:936727-05-8 |
Tezacaftor (VX-661) | | 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1- dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide | 1152311-62-0 |
Product Categories : APIs And Intermediates > Caftor Series Intermediates
Privacy statement: Your privacy is very important to Us. Our company promises not to disclose your personal information to any external company with out your explicit permission.
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Privacy statement: Your privacy is very important to Us. Our company promises not to disclose your personal information to any external company with out your explicit permission.