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Home > Products > APIs And Intermediates > Caftor Series Intermediates > Ivacaftor (VX-770) CAS: 873054-44-5

Ivacaftor (VX-770) CAS: 873054-44-5

Ivacaftor (VX-770) CAS: 873054-44-5

Payment Type: L/C,T/T,D/P
Incoterm: FOB,CIF,CIP
Min. Order: 0.01 Kilogram
Delivery Time: 3 Days

Basic Info

    Model No.: DM 873054-44-5

Additional Info

    Packaging: As required

    Productivity: Stock Available

    Transportation: Ocean,Air,Courier

    Place of Origin: Hebei,China

    Supply Ability: As per order

    Certificate: ISO9001

    Port: Shanghai,Shenzhen,Hangzhou

Product Description

Strong Products Ivacaftor(VX-770) CAS:873054-44-5 99%+


Product Name: N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Cas No.: 873054-44-5

Appearance:White Powder

Purity:99%+

Package&Shipping:

Package:Double PE Bag with Foil Bag or As required

Delivery time:Stock available

Port:Any port in China


iva

Ivacaftor is an orally bioavailable potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) that improves chloride transport.It increases the forskolin-induced CFTR-mediated epithelial current in cells expressing the G551D missense mutation associated with severe cystic fibrosis by approximately 4-fold (EC50 = 100 nM) but has no effect on current in the absence of forskolin. Ivacaftor increases chloride secretion in cultured human cystic fibrosis bronchial epithelial cells carrying the G551D mutation on one allele and the common ΔF508 processing mutation on the other allele. It binds CFTR directly and leads to CFTR channel opening via an ATP-independent mechanism.Formulations containing ivacaftor have been used in the treatment of cystic fibrosis in patients carrying one or more mutations in the CFTR gene.


Our productions of Ivacaftor(VX-770) Intermediates:

Ivacaftor

(VX-770)


N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

CAS: 873054-44-5

Iva-INT


4-oxo-1,4-dihydroquinoline-3-carboxylic acid

CAS: 13721-01 -2

Iva-INT


5-amino-2,4-di-tert-butylphenol hydrochloride

CAS: 873055-58-4 (base)


Other project related

Lumacaftor (VX-809)


3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)

Benzoic Acid

CAS:936727-05-8

Tezacaftor (VX-661)


1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-

dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide

1152311-62-0


Looking for ideal Vertex Ivacaftor Fda Manufacturer & supplier ? We have a wide selection at great prices to help you get creative. All the Ivacaftor Kalydeco Fda Approval are quality guaranteed. We are China Origin Factory of Kalydeco Cystic Fibrosis. If you have any question, please feel free to contact us.

Product Categories : APIs And Intermediates > Caftor Series Intermediates

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