Shijiazhuang Dingmin pharmaceutical Sciences Co.,Ltd
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Model No.: CAS No. 1110813-31-4
Brand: DM
Grade Standard: Medicine Grade
Type: Chemical Reagent
State: Solid
Volatile: Not Volatile
Packaging: double PE with aluminium foil bag
Productivity: 100kg/month
Transportation: Ocean,Air
Place of Origin: Hebei,China
Supply Ability: 100kg/month
Certificate: ISO9001
Port: Shanghai
Payment Type: L/C,T/T,Paypal
Incoterm: FOB,CIF
Dacomitinib (PF299804) is an effective, irreversible pan-erbb inhibitor that ACTS most effectively on EGFR,
with an IC50 of 6nM, and efficiently on NSCLCs with EGFR or ERBB2 mutants (anti-gefitinib) and EGFRT790M mutants.
Dacomitinib (PF299804), which name is (E)-N-[4-(3-chloro-4-fluoroanilino)-7- methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide,
is a potent, orally available, highly selective, irreversible small-molecule tyrosine kinase inhibitor (TKI) of tyrosine kinase human epidermal
growth factor receptors (HER) 1 (EGFR), HER2, and HER4. It is most effective against EGFR with IC50 of 6 nM.
It is highly effective against NSCLCs carrying EGFR or ERBB2 mutant (anti-Gefitinib) and EGFR T790M mutant.
Technical Data Sheet
| Item | Dacomitinib |
| CAS | 1110813-31-4 |
| MF | C24H25ClFN5O2 |
| MW | 469.9390032 |
| Boiling point | 665.7±55.0 °C(Predicted) |
| Density | 1.344 |
| form | White solid. |
| pka | 12.05±0.43(Predicted) |
| Brand | DM |
| Model Number | |
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