Shijiazhuang Dingmin pharmaceutical Sciences Co.,Ltd
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Model No.: DM 2353-33-5
Function: Specialist Drugs
Certification: GMP
Grade Standard: Medicine Grade
Type: Chemical Reagent
State: Solid
Volatile: Not Volatile
Purity: 99%
Appearence: White Powder
Packaging: 25kg/Drum or As required
Productivity: STOCK AVAILABLE
Transportation: Ocean,Air
Place of Origin: HEBEI,CHINA
Certificate: ISO9001
Port: Shanghai,Shenzhen,Qingdao
Payment Type: L/C,T/T,D/P,Others
Incoterm: FOB,CIF
Decitabine 5-aza-2'-deoxycytidine Cas 2353-33-5:
Product Name:Decitabine
Synonyms:4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-on;
5-AZA-CDR; 5-Aza-2'-deoxycytidine
CAS No:2353-33-5
Molecular Formula: C8H12N4O4
Moculer weight: 228.21
EINECS:219-089-4
Appearence: White to Off-white powder
COA: can be requested
Storage condition: keep in seal, cool and dry place
Stability: Stable. May be light or air sensitive. Incompatible with strong oxidizing agents.
Cyproterone acetate has antagonistic properties towards the 5-Aza-2'-Deoxycytidine, has been reported to cause phosphorylation inhibition of 2'-deoxycytidine in certain cells and the incorporation of 2'-deoxycytidine into DNA. Experiments have shown that this compound induces changes in the differentiated state of cultured mouse embryo cells and additionally inhibits Dnmt (DNA methyltransferase). DNA methylation has been noted to be important in determining apoptotic susceptibility to histone deacetylase inhibitors, and its prevention can cause gene silencing and transcriptional repression. Other studies suggest that cell exposure to 5-Aza-2'-Deoxycytidine causes a change in replication timing, reactivation of repressed genes, and decondensation of heterochromatin. Furthermore, this agent demonstrates the ability to induce histone hyperacetylation in murine centromeric heterochromatin and also affect intranuclear distribution of histone deacetylase 2.
COA of Decitabine 5-aza-2'-deoxycytidine CAS 2353-33-5:
ANALYSIS SPECIFICATION RESULTS Appearance Fine powder Complies Odor Characteristic Complies Extract Ratio 10:1 Complies Sieve analysis 100% pass 80 mesh Complies Loss on Drying ≤5.0% 2.98% Residue on Ignition ≤5.0% 2.32% Heavy Metal <10ppm Complies As <2ppm Complies Residual Solvents Eur.Pharm. Complies Total Plate Count <1000/g 145/g Yeast & Mold <100/g 62/g E.Coli Negative Complies Salmonella Negative Complies
Microbiology
Our productions of Decitabine Intermediates:
Product Categories : APIs And Intermediates > Decitabine Intermediates
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